1374 CARBON MONOXIDE EFFECT ON BRAIN OXIDATIVE METABOLISM IN NEWBORN PIGLETS

Effect of carbon monoxide on protein metabolism in mouse brain.

Effect of Erythropoietin on Serum Brain-derived Biomarkers after Carbon Monoxide Poisoning in Rats

Objective(s) Erythropoietin has been shown to exert neuroprotective effects in a variety of CNS injury models. Elevation of serum S100β, as a glial damage marker and myelin basic protein (MBP) has been reported to occur in acute carbon monoxide (CO) poisoning. The aim of this study was to evaluate the effect of erythropoietin (EPO) on serum S100β and MBP levels after CO poisoning in rats. Mat...

Carbon monoxide contributes to hypotension-induced cerebrovascular vasodilation in piglets.

The gaseous compound carbon monoxide (CO) has been identified as an important endogenous biological messenger in brain and is a major component in regulation of cerebrovascular circulation in newborns. CO is produced endogenously by catabolism of heme to CO, free iron, and biliverdin during enzymatic degradation of heme by heme oxygenase (HO). The present study was designed to test the hypothes...

Oxygen dependency of cerebral oxidative phosphorylation in newborn piglets.

Changes in hemoglobin oxygenation and oxidation state of the CuA centre of cytochrome oxidase were measured with full spectral near infrared spectroscopy simultaneously with phosphorus metabolites using nuclear magnetic resonance 31P spectroscopy at high time resolution (10 seconds) during transient anoxia (FiO2 = 0.0 for 105 seconds) in the newborn piglet brain. During the onset of anoxia, the...

effect of erythropoietin on serum brain-derived biomarkers after carbon monoxide poisoning in rats

objective(s) erythropoietin has been shown to exert neuroprotective effects in a variety of cns injury models. elevation of serum s100β, as a glial damage marker and myelin basic protein (mbp) has been reported to occur in acute carbon monoxide (co) poisoning. the aim of this study was to evaluate the effect of erythropoietin (epo) on serum s100β and mbp levels after co poisoning in rats. mater...